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Using Plasma HPV related DNA and RNA to Follow Response of Cervical Cancer to Surgery, Radiation, and Chemotherapy

  • Status
    Accepting Candidates
  • Age
    18 Years - 89 Years
  • Sexes
    Female
  • Healthy Volunteers
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Description

The vast majority of cervical cancer is caused by the human papillomavirus (HPV). Oncogenesis occurs through incorporation of viral DNA into nuclear DNA. We postulate that tumor cell death leads to circulating HPV DNA. We expect its level at a steady state to represent the patient’s tumor burden. Similarly, acute spikes in HPV DNA in the first days after radiation indicate tumor response to effective treatment. If this simple approach proves true, timely information on tumor response could revolutionize the therapy of cervical cancer. We will test two methods, the standard polymerase chain reaction (PCR)-based assay and the commercially available branched DNA (Quantivirus HPV [DNA]) for their ability to detect tumor response following surgery, radiation, and chemotherapy. PCR is a laboratory technique used to rapidly amplify and detect specific segments of DNA, allowing precise identification and quantification of genetic material. The branched DNA Quantivirus assay was developed by 萝莉社 scientists and has the advantage of international utility, greater deploy-ability, lower cost, and quantitative accuracy. A potential advantage of the Quantivirus assay is allowance for more frequent testing and, therefore, more timely outcome information to aid physician decision making and evaluate treatment progress. As a weakness, it has a higher limit of detection. We will perform a 9 month feasibility study to examine the side by side utility of both the PCR and Quantivirus HPV DNA assays in predicting treatment response.

Neither test will be used as a form of therapy (and will not guide or alter standard of care therapy), nor does the study provide any additional interventional therapy to participants - the study is strictly observational.


Details

Protocol number 202501136

Eligibility

inclusion:

1:18 yrs and older patients who have been diagnosed HPV associated squamous cancer of uterine cervix with active, measurable /evaluable disease.

2: Agreeable to multiple blood samples and a cervical swab.

Exclusion:

Diagnosed with other malignancies requiring cancer directed therapy.

Lead researcher

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